Enhancing teaching and learning through dialogue: a student and staff partnership model

This paper explores a model for developing student and staff partnerships to enhance the quality of teaching and learning and situates the model in literature on student engagement. The model enables staff and students to step outside their normal roles and the traditional student-teacher relationship into a less pre-defined mode of interaction and liminal space where conversations about teaching and learning can take place. At the most transformative, this model enables academic staff to get a sense of learner perspectives and to view students as partners and collaborators while students develop insights into the perspectives of staff. The authors argue that the model represents an innovative approach to engaging students in a meaningful way in enhancing teaching and learning and has the potential to reframe the student-teacher relationship into a more collaborative one that goes beyond listening to students

The role of drug transporters in the kidney: lessons from tenofovir

Tenofovir disoproxil fumarate, the prodrug of nucleotide reverse transcriptase inhibitor tenofovir, shows high efficacy and relatively low toxicity in HIV patients. However, long-term kidney toxicity is now acknowledged as a modest but significant risk for tenofovir-containing regimens, and continuous use of tenofovir in HIV therapy is currently under question by practitioners and researchers. Co-morbidities (hepatitis C, diabetes), low body weight, older age, concomitant administration of potentially nephrotoxic drugs, low CD4 count, and duration of therapy are all risk factors associated with tenofovir-associated tubular dysfunction. Tenofovir is predominantly eliminated via the proximal tubules of the kidney, therefore drug transporters expressed in renal proximal tubule cells are believed to influence tenofovir plasma concentration and toxicity in the kidney. We review here the current evidence that the actions, pharmacogenetics, and drug interactions of drug transporters are relevant factors for tenofovir-associated tubular dysfunction. The use of creatinine and novel biomarkers for kidney damage, and the role that drug transporters play in biomarker disposition, are discussed. The lessons learnt from investigating the role of transporters in tenofovir kidney elimination and toxicity can be utilized for future drug development and clinical management programs

Physical Vulnerabilities from Wildfires: Flames, Floods, and Debris Flows

Humans live in or adjacent to wildland ecosystems that burn periodically and are part of nearly all ecosystems that are in the pyrosphere. There are many hazards posed by wildfire and certain consequences of living in these ecosystems. Most are associated with wildfire, but the increased use of prescribed fire is an issue because of associated risks with human attempts to manage ecological goals. The hazards posed by wildfire involve cultural and economic loss, social disruption, infrastructure damage, human injury and mortality, damage to natural resources, and deterioration in air quality. The economic and human health and safety costs are on the rise due to increasing wildland-urban interface problems and extreme wildfire behavior brought on by climate change. In the past, urban fires have been the greatest threat to human health and safety killing over 100,000 people. World ecosystems have been modified extensively by fire. We live on a “fire planet.” With larger human populations and a changing, drying climate, the impact of fire on humans and the hazards faced by our natural and developed world will continue to increase. The increase in wildfire hazards in the twenty-first century will require higher levels of training, increased investments in wildfire personnel and infrastructure, greater wildfire awareness, and improved planning to reduce fire impacts

Age-related changes in arterial blood-gas variables in Holstein calves at moderate altitude

Includes bibliographical references (pages 19-20).The goal of this study was to determine whether peripheral oxygen delivery and efficacy of alveolar-arterial oxygen (A-a O2) transfer, as estimated from the A-a O2 pressure gradient, are compromised in Holstein calves at moderate altitude. The primary objective was to evaluate age-related changes in arterial blood-gas variables, L-lactate, and hematocrit in healthy calves. The secondary objective was to determine if coughing and nasal discharge, commonly used indicators of respiratory disease, are associated with A-a O2 gradient. Arterial blood-gas tensions were evaluated in a cohort of 61 dairy calves on one farm at moderate altitude (1,601 m to 1,696 m). Sampling was performed on four occasions at approximately 10, 38, 150, and 261 days of age. Hyperventilation, as indicated by hypocapnia, was evident in calves of all ages. Increasing age was associated with a nonlinear increase in arterial oxygen tension (P<0.001) and a nonlinear decrease in A-a O2 gradient (P<0.001). The mean A-a O2 gradient at 10 and 38 days of age was over 18 mmHg, indicating poor efficacy of oxygen transfer. Cough score (P=0.02) but not nasal score (P=0.32) was associated with an in increase in A-a O2 pressure gradient. Mean hematocrit remained low (<27%) despite hypoxemia. From 38 days of age, median L-lactate concentration remained over 1.5 mmol/L, indicating substantial anaerobic respiration due to inadequate oxygen delivery. Twenty-five percent of calves were treated for respiratory disease. The maximum age at first treatment was 102 days. In conclusion, there was a nonlinear improvement in A-a O2 transfer efficacy with increasing age, but peripheral oxygen delivery remained compromised. Hyperventilation and impaired A-a O2 transfer due to functional immaturity of the pulmonary system may be risk factors for respiratory disease in dairy calves at moderate altitude.Published with support from the Colorado State University Libraries Open Access Research and Scholarship Fund

Local DC electricity generated by photovoltaics (PV): Transforming the electricity infrastructure of the 21st Century

United States aging electricity infrastructure of generation, transmission and distribution facilities was built over the course of a century and is dominated by alternating current (AC). Most of the loads around us are direct current (DC) load. Commercial buildings have more than 80% DC loads. DC has many advantages over AC. Due to the advancements in power electronics today, DC infrastructure can be implemented with all the advantages of saving energy and improved reliability of the grid. By doing measurements of cell phones we will demonstrate the advantages of DC source over AC. We expect energy saving of about 25-30% by using DC in place of AC. At Edison\u27s time there was no local source of DC electricity. Today solar panels are available and the installed PV system cost is as low as $1.50 per peak watt. Due to growth of electric vehicles and grid storage, battery cost is also decreasing every day. Tesla (an electric car manufacturer) is going to build a Giga watt battery manufacturing plant in US. The combination of PV and battery storage will transform the electricity infrastructure of the 21st century

Motion Tracking System in Surgical Training

Introduction: Simulation technology is evolving and becoming the focus of attention in surgical training. The development of this technology in assessing open surgical skills is far behind when compared to minimally invasive surgery (MIS) training. Surgical skills such as suturing and tying surgical knots are assessed by an observational tool. It is labour-intensive and time-consuming. Therefore, we explored the potential use of motion tracking system as a non-observational assessment tool for basic surgical skills

Gastrointestinal Foreign Bodies

Retained foreign bodies within the gastrointestinal tract (GIT) are common emergency presentations. The majority will pass spontaneously or be removed endoscopically, but a few selected cases may require emergency surgery for removal. This chapter reviews the management of foreign bodies within the GIT including both instances of foreign body ingestions and foreign body insertions. The scope of this chapter is not limited to evidence‐based data on selection of cases for conservative management but also includes data on endoscopic and surgical management

The association between paternal and adolescent depressive symptoms: evidence from two population-based cohorts

BACKGROUND: Incidence of depression increases markedly around age 13 years, and nearly three-quarters of adults report that their mental health problems started in adolescence. Although maternal depression is a risk factor for adolescent depression, evidence about the association between paternal and adolescent depression is inconclusive, and many studies have methodological limitations. We aimed to assess the association between paternal and adolescent depressive symptoms in two large population-based cohort studies. METHODS: We used data for two-parent families from two representative prospective cohorts in Ireland (Growing up in Ireland [GUI]) and the UK (Millennium Cohort Study [MCS]). Parental depressive symptoms were measured with the Centre for Epidemiological Studies Depression Scale in the GUI cohort when children were 9 years old, and the Kessler six-item psychological distress scale in the MCS cohort when children were 7 years old. Adolescent depressive symptoms were measured with the Short Mood and Feelings Questionnaire (SMFQ) at age 13 years in the GUI cohort and age 14 years in the MCS cohort. We analysed data using linear regression models, before and after adjustment for confounders, in both multiply imputed and complete case samples. FINDINGS: There were 6070 families in GUI and 7768 in MCS. After all adjustments, a 1 SD (three-point) increase in paternal depressive symptoms was associated with an increase of 0·24 SMFQ points (95% CI 0·03-0·45; p=0·023) in the GUI cohort and 0·18 SMFQ points (0·01-0·36; p=0·041) in the MCS cohort. This association was independent of, and not different in magnitude to, the association between maternal and adolescent depressive symptoms (Wald test p=0·435 in the GUI cohort and 0·470 in the MCS cohort). INTERPRETATION: Our results show an association between depressive symptoms in fathers and depressive symptoms in their adolescent offspring. These findings support the involvement of fathers as well as mothers in early interventions to reduce the prevalence of adolescent depression, and highlight the importance of treating depression in both parents. FUNDING: Department of Children and Youth Affairs and Economic and Social Research Council